Abstract
N-Aminoindoline derivatives were prepared and their 5-lipoxygenase inhibitory activities were evaluated in vitro and compared with those of phenidone and NDGA. Compound 4 presents the most effective 5-LO inhibition.
MeSH terms
-
Antioxidants / chemical synthesis*
-
Antioxidants / chemistry
-
Antioxidants / pharmacology
-
Arachidonate 5-Lipoxygenase / metabolism
-
Hydroxyurea / analogs & derivatives*
-
Hydroxyurea / chemistry
-
Hydroxyurea / pharmacology
-
Indoles / chemical synthesis*
-
Indoles / chemistry
-
Indoles / pharmacology
-
Lipoxygenase Inhibitors* / chemical synthesis*
-
Lipoxygenase Inhibitors* / chemistry
-
Lipoxygenase Inhibitors* / pharmacology
-
Pyrazoles / pharmacology
Substances
-
Antioxidants
-
Indoles
-
Lipoxygenase Inhibitors
-
Pyrazoles
-
indoline
-
Arachidonate 5-Lipoxygenase
-
phenidone
-
zileuton
-
Hydroxyurea