N-Aminoindoline derivatives as inhibitors of 5-lipoxygenase

Bioorg Med Chem Lett. 2001 Mar 26;11(6):845-8. doi: 10.1016/s0960-894x(01)00077-4.

Abstract

N-Aminoindoline derivatives were prepared and their 5-lipoxygenase inhibitory activities were evaluated in vitro and compared with those of phenidone and NDGA. Compound 4 presents the most effective 5-LO inhibition.

Publication types

  • Comparative Study

MeSH terms

  • Antioxidants / chemical synthesis*
  • Antioxidants / chemistry
  • Antioxidants / pharmacology
  • Arachidonate 5-Lipoxygenase / metabolism
  • Hydroxyurea / analogs & derivatives*
  • Hydroxyurea / chemistry
  • Hydroxyurea / pharmacology
  • Indoles / chemical synthesis*
  • Indoles / chemistry
  • Indoles / pharmacology
  • Lipoxygenase Inhibitors* / chemical synthesis*
  • Lipoxygenase Inhibitors* / chemistry
  • Lipoxygenase Inhibitors* / pharmacology
  • Pyrazoles / pharmacology

Substances

  • Antioxidants
  • Indoles
  • Lipoxygenase Inhibitors
  • Pyrazoles
  • indoline
  • Arachidonate 5-Lipoxygenase
  • phenidone
  • zileuton
  • Hydroxyurea